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Applications
Postural Vasoconstriction
On changing posture from a supine position to standing, the microvasculature of the lower limbs vaso-constricts. This is the veno-arteriolar reflex (VAR) and the associated change in blood flow can be assessed by laser Doppler. The VAR is a mechanism that protects the delicate microvasculature of the lower limbs from damage due to excess hydrostatic blood pressure. The impairment of the VAR is seen in diabetes and more recently in primary biliary cirrhosis.
Although monitoring can be used, imaging will provide multiple LD flux measurements that can be averaged. The VAR index is Flux average in the dependent position / Flux average in the supine position x 100%. Observed values for VAR: normal healthy = 18%; diabetic without neuropathy = 29%; diabetic with neuropathy = 54%.
Equipment Recommendations
The moorLAB-LDF with a LP1T/7 probe can be used in conjunction with moorLAB-PC software.
Laser Doppler Monitor
moorLAB-LDF
Advanced, laser Doppler blood flow and temperature monitor
Accessories
SOFTWARE-LAB-RESEARCH-1VX - Advanced aquisition and analyses functions to collect signals and automate control protocol modules
LP1T/7 - A combined temperature and optic probe that delivers light at a right angle to the probe cable with 8 collecting fibres in a 2mm ring with a central delivery fibre
What Next?
Contact us to discuss your specific needs and to request your copy of our free Application Note which includes a detailed experimental method and practical suggestions. We also offer no obligation on-site visits so you can test the equipment in your facility.