Applications

Post Occlusive Reactive Hyperaemia – PORH

The increase in microvascular blood flow following arterial occlusion, Post Occlusive Reactive Hyperaemia (PORH), can be assessed using the non-invasive laser Doppler technique. Following release of the arterial occlusion there is a marked transient increase in microvascular blood flow to the ischaemic tissues.

Laser Doppler derived Post Occlusive Reactive Hyperaemia measurements have been shown to be highly reproducible (Yvonne-Tee et al, 2005). The mechanisms behind PORH are believed to be a combination of: myogenic relaxation of the vessels (Patterson, 1956), release of local mediators and metabolites from the ischaemic tissue (Kontos et al, 1965) and more recently the involvement of sensory nerves (Minson & Lorenzo, 2007). As a result of unknown mechanisms behind PORH there is extensive research in this area. Previous studies have shown the Post Occlusive Reactive Hyperaemia response to ischaemia shows distinct patterns that are associated with cardiovascular risk i.e. area under curve (AUC) and peak flux following the period of ischaemia (Strain et al, 2005. Yamamoto-Suganuma et al, 2009).

The moorVMS-VASC system enables rapid, reproducible and user-friendly measurement of Post Occlusive Reactive Hyperaemia (PORH). The user friendly PC software enables protocols to be written which exactly match user requirements for individual experimental conditions – whilst allowing your institution to create, save and repeat an assessment specifically designed for your institution easily enabling a reproducible method to be performed.