应用
Endothelial Dysfunction
The endothelium is the lining of blood vessels of the circulatory system, with a fundamental role in vasodilation. Studies of endothelial Dysfunction are widespread and include a number of areas of both clinical and pre-clinical research. Fundamental to such studies are the techniques of laser Doppler monitoring, imaging and Laser Speckle combined, for example, with pressure cuff challenges, iontophoresis and/ or skin heating to provide reproducible challenges. The advantage of imaging is that blood flow can be imaged and recorded over an area of interest rather than a single point measurement, thus results are both more reliable and show better reproducibility.
Techniques | Field of study | Reference |
Iontophoresis | Raynaud’s Phenomenon | Shepherd et al, 2019 |
Ethnicity | Maley et al, 2017 | |
Glaucoma | Bukhari et al, 2019 | |
Cardiovascular disease | Frank et al. 2010 George et al. 2009 Jadhav et al. 2007 Khan et al. 2008 |
|
Diabetes | Beer et al. 2008 Franklin et al. 2008 |
|
Peripheral neuropathy | Brooks et al, 2008 | |
Systemic sclerosis | Gunawardena et al 2007a Murray et al. 2008 |
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Dermal microvascular blood flow | Agarwal et al. 2010 | |
Idiopathic inflammatory myopathy | Gunawardena et al 2007b | |
Skin heating & Iontophoresis | Vascular reactivity | Beed et al, 2009 |
Heating | Vascular reactivity | Casey et al, 2020 Del Pozzi et al, 2016 Minson et al, 2002 |
PORH | Endothelial function | Yamamoto-Suganuma & Aso, 2009 |
Endothelial function | Spaan et al, 2010 | |
Microvascular function – CVD | Shore et al, 2005 | |
PORH & Heating | Endothelial Function & Ethnicity | Petrofski et al, 2013 Strain et al, 2010 |
Equipment Recommendations
It is difficult to make a definitive recommendation due to the wide scope of challenges used, coupled with the use of both monitoring and imaging, and the number of suitable imagers available. Systems can be offered to suit a range of budgets though and you are welcome to contact us to discuss further. Extended use of equipment for other research fields might influence the final decision but an ideal investigation lab would include either the speckle contrast imager (moorFLPI-2) or laser Doppler monitor (moorVMS-LDF), iontophoresis controller (moorVMS-ION) and skin heater controller (moorVMS-HEAT) and pressure cuff controller (moorVMS-PRES) options.
激光散斑成像系统
moorFLPI-2
Full-field, video frame rate blood flow imaging
附件
moorVMS-ION - Transdermal drug delivery by iontophoresis
moorVMS-HEAT - Skin heater module offers flexible and reproducible skin heating protocols for flow/ oxygen response assessments
moorVMS-PRES - Automatic pressure cuff control for routine microvascular testing
激光多普勒血流监测系统
moorVMS-LDF
先进的激光多普勒血流和温度监测
附件
moorVMS-PRES - Automatic pressure cuff control for routine microvascular testing
VP1T - A combined temperature and optic probe that delivers light at a right angle to the probe cable
CUFF-TOE - Toe Pressure Cuff with airline and quick fit connector
What Next?
Contact us to discuss your specific needs and to request your copy of our free Application Note which includes a detailed experimental method and practical suggestions. We also offer no obligation on-site visits so you can test the equipment in your facility.