moorLAB

#moorLAB

Tissue blood flow monitoring

  • Moor Instruments have consistently provided excellent help and support for my research.

    Kim Gooding, PhD
    University of Exeter Medical School

  • It goes without saying that the company's imaging technology itself is superb!

    Gourav Banerjee
    Leeds Beckett University

  • We can't recommend Moor instruments highly enough. The technology is at the cutting edge and the support second to none.

    Paul Sumners, PhD
    London South Bank University

  • In a nutshell, moorFLPI-2 is the most user-friendly system for studying cerebral blood flow regulation in rodents.

    Chia-Yi (Alex) Kuan, MD, PhD
    Emory University School of Medicine

  • I expect to be using Moor Instrument’s technology for many years to come!

    Faisel Khan, PhD
    Ninewells Hospital & Medical School

  • We have found Moor equipment to be extremely dependable and innovative.

    Dean L. Kellogg, Jr., MD, Ph.D
    University of Texas Health Science Center

  • I cannot rate the company or the staff highly enough.

    Jim House, PhD
    University of Portsmouth

  • Laser Doppler Imager is a standard accurate method we now use in our cerebral blood flow and brain perfusion in our laboratory.

    Momoh A. Yakubu, PhD
    Texas Southern University

This system has now been superseded by the moorVMS-LDF, for full details please click here.

The moorLAB was designed specifically for the research market. It uses identical signal processing and internal optical design as found in our DRT4 model so there was absolutely no compromise in the measurement quality. We left off features that are non essential for researchers leaving an easy to use, high quality yet competitively priced laser Doppler monitor. The system was available in a 1,2,3 or 4 channel configuration and upgrade is a very simple matter of connecting extra satellite channels to the base Server unit. Additional satellite channels can be purchased separately at any time.

The moorLAB will interface directly with your PC through either a USB or Serial port for data collection and analysis using our Windows based package, moorSOFT for Windows/moorLAB. All software is produced in-house to allow us full control over specification and functionality. If you use a data acquisition system already then data is also output as an analogue signal (0 to 10V) through convenient BNC connectors on the rear panel of the Server.

This system has now been superseded by the moorVMS-LDF, for full details please click here.

The following products are AVAILABLE TO BUY ONLINE and work with the moorLAB


This system has now been superseded by the moorVMS-LDF, for full details please click here.

This section lists the more common questions our customers have about the moorLAB system. If you have a question you would like answered that does not appear below then please email us. We are happy to help!


Q. How is data transferred from the moorLAB system?
A. Unlike the DRT4 the moorLAB does not have an internal data memory so you will need to connect the system to a PC, chart recorder or data acquisition system to permanently record the trace. Every moorLAB will connect to your PC running Moorsoft for Windows/moorLAB via USB or serial ports. Convenient BNC connections are also provided on the rear panel to link straight to your chart recorder or data acquisition system (0 to 10 Volts) fully scalable.

Q. How many sites can I measure from simultaneously with the moorLAB?
A. The moorLAB offers flexible channel expansion from the base single channel Server with additional Satellites. Up to 3 Satellites can be added to one Server so you can measure from 1,2,3 or 4 sites depending on your configuration.

Q. How often should the probes be calibrated?
A. We have some customers who calibrate daily and others less regularly. The important thing to bear in mind is that the room temperature should be close to the same each time you calibrate. There is a risk of 'over calibration' - excessive calibration throughout the day - which can be counterproductive if there are large temperature swings. This can result in changes in the Brownian motion of the polystyrene microspheres. We would normally recommend calibrating at least weekly during the course of a scientific investigation. Calibration is also a good indicator of probe condition. A damaged probe will not calibrate!

Q. Can I measure other signals at the same time as flux?
A. Yes, the moorLAB outputs Flux, Conc, Speed and DC to PC (Moorsoft for Windows/moorLAB). Flux+Conc or Flux+DC are output via analogue BNC connections. moorLAB signals can be integrated with those from other devices if you have spare input channels on your data acquisition system.

Q. Should the skin be cleaned before measurements?
A. Yes - we recommend using an alcohol wipe. Dry or flaky skin can be removed with sticky tape.

This system has now been superseded by the moorVMS-LDF, for full details please click here.

The list below contains a selection of references citing use of moorLAB. The list below is a small selection. Please contact us for reference lists on your chosen subject.


Martin Katzman, Sylvie Cornacchi, Aimee Coonerty-Femiano, Bronwen Hughes, Monica Vermani, Lukasz Struzik and Brian M Ross.
Methyl Nicotinate-Induced Vasodilation in Generalized Social Phobia.
Neuropsychopharmacology (2003) 28, 1846-1851

Mitja Benedičič, David Debevc, Vinko V. Dolenc, and Roman Bošnjak.
Laser-Doppler Flowmetry and Horner’s Syndrome in Patients with Complete Unilateral Damage to the Parasellar Sympathetic Fibers During Cavernous Sinus Surgery.
Croatian Medical Journal, 2006 47:292.7

Brett J. Wong, Brad W. Wilkins, Lacy A. Holowatz, and Christopher T. Minson.
Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation.
J Appl Physiol 95: 504-510, 2003

Thompson CS, Holowatz LA, Kenney WL.
Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans.
J Physiol Regul Integr Comp Physiol 288

This system has now been superseded by the moorVMS-LDF, for full details please click here.

Moor Instruments are committed to product development. We reserve the right to change the specifications below without notice.


OPTICS

Laser Safety Classification
Class 3A per BSEN 60825-1:1994
Class 1M per IEC 60825-1:2001
Class 1 per 21 CFR 1040.10 and 1040.11
Output power 1.6mW max.
Wavelength 785nm + 10nm
Angular spread of laser light from probe tip 30° + 3°
All specifications include cumulative measured uncertainties and expected increases in values after manufacture

SIGNAL PROCESSING

Bandwidth: high pass 20Hz Low pass selectable 3KHz, 15KHz, 22KHz
Output time constants: 0.02s, 0.1s, 0.5s, 1.0s, 3.0s
Automatic gain control and zeroing

OUTPUTS

Digital LCD screen display
40Hz maximum data rate
0-1000 arbitrary perfusion units
1 serial interface RS232 optically isolated
8 analogue outputs 0-10v D/A 12 bit (external bus)
1 moorLAB Bus

INTERNAL SOFTWARE FEATURES

Flash memory programmable from PC
Output scale adjustment
Filter bandwidth selection
Calibration — storage of four probe scaling constants per channel

GENERAL

Universal voltage switch-mode power supply range 84 to 264v at 40VA, 50 to 60 Hz
Dimensions W H D mm
SERVER 275 x 60 x 260
SATELLITE 275 x 110 x 280
Weight kgs
SERVER 3.5
SATELLITE 1.5

STORAGE AND TRANSPORT CONDITIONS

Temperature 0-45oC
Humidity 0-80% RH
Atmospheric pressure 500-1060hPa
Type of protection against electric shock — Class 1
Degree of protection against electric shock — Type BF
Degree of protection against ingress of liquid — IPXO (not protected)
Degree of protection against flammable anaesthetics — equipment not suitable for use in the presence of a flammable anaesthetic mixture with air or with nitrous oxide
Mode of operation: continuous

PERFUSION MEASUREMENTS

FLUX
Accuracy: ± 10%, relative to Moor Instruments ‘standard’ moorLAB
Precision: ± 3% of measurement value
Range: 0-1000 PU

CONC
Accuracy: ± 10%
Precision: ± 5% of measurement value
Range: 0-1000AU

DC
Accuracy: ± 10%
Precision: ± 3%
Range: 0-255

This system has now been superseded by the moorVMS-LDF, for full details please click here.

Moor Instruments manufacture a wide range of probes designed to help you assess flow from almost any tissue. We are more than happy to advise on your particular application but hope too that the following general notes are useful.


Skin probes are available with two main fibre configurations, twin or multi-fibre designs. Multi-fibre designs usually contain a ring of up to eight collecting fibres around a central delivery fibre. This provides an averaged signal for a larger tissue area than would otherwise be provided by the conventional twin fibre model.

Skin probes are usually fixed to the skin with a probe holder and double sided adhesive discs, although they can be used in other applications (e.g. bone, visceral measurements) and with other equipment (e.g. Iontophoresis). Please refer to the Accessories and Iontophoresis catalogues. DRT4 users can specify combined laser Doppler and temperature probes.

The standard length for all probes is 2 metres. Longer lengths can be supplied on request (code PXL). The range of probe holders for these (and other) probes is described in the accessories page.

Needle probes are amongst the most versatile designs. They can be used for surface measurements, inserted into tissue or used for single vessel measurements. The compact design also lends itself to measurements in tissues with restricted access, e.g. teeth, conjunctiva and where micromanipulation is required.

Probes can be fixed in position over tissue with a normal laboratory manipulator by clamping onto the black acetal shank.

Deeper measurements are possible by inserting the probe tip into tissue bulk, for which finer needles are suitable (VP4 and VP4s). The finest needles can be inserted directly into some tissues with the application of gentle pressure: for larger needles it may be necessary to puncture the tissue first with a hypodermic needle.

The use of specific probe holders can extend the application range of needle probes further still. Wet stick probe tips can be used to aid adhesion to moist/ mucosal surfaces. Dental putty can be used to create an individual probe holder for tooth measurement. Angled needle probes can be used to access hind teeth.

Although laser Doppler is not usually advocated for assessment of flow in single vessels, there is a role for the technique in the assessment of flow changes in small individual vessels. Moor manufactures a range of probe holders to aid this measurement.

Low profile designs are either used where access is difficult (e.g. oral mucosa) or to reduce application pressure if the probe is to be covered by bandages. Various designs are available, including the titanium disc probe and the near flat silicon probe.

MP10M100ST & MP10M200ST Master/ single fibre probe system. Master probes are twin fibre designs, acting as a link between the monitor and the single fibre probe. The Master probe connects to the single fibre probe via an optical in-line connector (order code PCP).

This system offers a number of advantages over more conventional probe designs. The benefits include;

1. Small diameter probes (down to 250micron) for minimally invasive measurements.

2. Wide choice of single fibre probes for diverse measurements. Just connect a new probe for a change to muscle, cerebral, gastric, organ or endoscopic (etc.) applications. This represents an economic solution if you intend to sample at a number of different tissue sites with a limited number of LDF channels.

3. Single fibre probes are supplied with re-usable, detachable connectors (order code PCN). Probes can be sterilised easily for re-use or treated as disposable (see P10d, P10k,P10s-TCG). Moor Instruments can also supply the materials for you to construct your own single fibre probes.

4. For longer-term measurements the Master can be disconnected to leave the single fibre in position between measurement periods.