Iontophoresis Controller

#moorVMS-ION

Transdermal drug delivery by iontophoresis

  • We have found Moor equipment to be extremely dependable and innovative.

    Dean L. Kellogg, Jr., MD, Ph.D
    University of Texas Health Science Center

  • Moor Instruments have consistently provided excellent help and support for my research.

    Kim Gooding, PhD
    University of Exeter Medical School

  • We can't recommend Moor instruments highly enough. The technology is at the cutting edge and the support second to none.

    Paul Sumners, PhD
    London South Bank University

  • I cannot rate the company or the staff highly enough.

    Jim House, PhD
    University of Portsmouth

  • It goes without saying that the company's imaging technology itself is superb!

    Gourav Banerjee
    Leeds Beckett University

  • In a nutshell, moorFLPI-2 is the most user-friendly system for studying cerebral blood flow regulation in rodents.

    Chia-Yi (Alex) Kuan, MD, PhD
    Emory University School of Medicine

  • I expect to be using Moor Instrument’s technology for many years to come!

    Faisel Khan, PhD
    Ninewells Hospital & Medical School

  • Laser Doppler Imager is a standard accurate method we now use in our cerebral blood flow and brain perfusion in our laboratory.

    Momoh A. Yakubu, PhD
    Texas Southern University

The moorVMS-ION iontophoresis controller is intended to provide the driving force for a range of clinical research applications that require drugs to be delivered by iontophoresis in order to monitor any associated changes in tissue perfusion.

The moorVMS-ION iontophoresis controller is intended to be used in conjunction with a range of Moor Instruments products, including:

  • Monitors: moorVMS-LDF, moorVMS-OXY
  • Imagers: moorFLPI-2, moorLDI2, moorLDLS2
  • Software: moorVMS-PC

Iontophoresis is a method of delivering ionic drugs into the skin. Normally non-lipophilic drugs, e.g. acetylcholine chloride, would remain on the skin surface and very little would diffuse into the skin. Iontophoresis is performed using an electrically conductive chamber filled with the non-lipophilic drug solution and a conductive pad, placed in contact with the patient’s skin. A small current flows between the chamber and conductive pad, causing the ions of the drug to convey the electrical current as they pass into the skin.

Please note: the moorVMS-ION iontophoresis controller it is not intended to deliver drugs for the treatment of illness or disease.

The following products are AVAILABLE TO BUY ONLINE and work with the moorVMS-ION


There are numerous references where our iontophoresis controllers are cited. The list below is a small selection. Please contact us for reference lists on your chosen subject.


Alam, T. a, Seifalian, a M. & Baker, D., 2005.
A review of methods currently used for assessment of in vivo endothelial function.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 29(3), pp.269-76.
Weblink

Forst, T. et al., 2005.
Impact of insulin on microvascular blood flow and endothelial cell function in the postprandial state in patients with Type 1 diabetes.
Journal of diabetes and its complications, 19(3), pp.128-32.
Weblink

Ferrell, W. R., Ramsay, J. E., Brooks, N., Lockhart, J. C., Dickson, S., McNeece, G. M., Greer, I. a, et al. (2002).
Elimination of electrically induced iontophoretic artefacts: implications for non-invasive assessment of peripheral microvascular function.
Journal of vascular research, 39(5), 447-55.

Frank, J. et al., 2009.
Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.
Nutrition, (November 2008), pp.58-62.

Franklin, V.L. et al., 2008.
Intensive insulin therapy improves endothelial function and microvascular reactivity in young people with type 1 diabetes.
Diabetologia, 51(2), pp.353-60.

George, T.W. et al., 2009.
Effects of chronic and acute consumption of fruit- and vegetable-puree based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism.
The Proceedings of the Nutrition Society, 68(2), pp.148-61.

Jadhav, S. et al., 2007.
Reproducibility and repeatability of peripheral microvascular assessment using iontophoresis in conjunction with laser Doppler imaging.
Journal of cardiovascular pharmacology, 50(3), pp.343-9.

Jones, B.L. et al., 2009.
Assessment of histamine pharmacodynamics by microvasculature response of histamine using histamine iontophoresis laser Doppler flowimetry.
Journal of clinical pharmacology, 49(5), pp.600-5.

Khan, F. et al., 2008.
The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors.
Atherosclerosis, 200(2), pp.374-9.

Ramsay, J. E., Ferrell, W. R., Greer, I. A., & Sattar, N. (2002).
Factors critical to iontophoretic assessment of vascular reactivity: implications for clinical studies of endothelial dysfunction.
Journal of cardiovascular pharmacology, 39(1), 9-17.

Turner, J., Belch, J. J. F., & Khan, F. (2008).
Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis.
Trends in cardiovascular medicine, 18(4), 109-16.

Moor Instruments are committed to product development. We reserve the right to change the specifications below without notice.


Output Current

Range: 1 – 250 µA
Accuracy: ± 0.5 µA
Precision: ± 0.1 µA
Step: 0.1 µA (1-10 µA)
1.0 µA (10-250 µA)

Compliance Voltage

27 V ±2V

Current Measurement

Resolution: 0.1 µA
Accuracy: ± 0.5 µA
Precision: ± 0.1 µA

Voltage Measurement

Resolution: 10 mV (<10 V)
100 mV (≥10 V) on front panel display
Accuracy: ± 100 mV

Resistance Measurement

Range: 1 k – 20 MΩ
Accuracy: ± 5 % 1k – 20 MΩ, Output Voltage >0.2 V

Countdown Timer

Range: 10 sec – 60 mins
Step: 1 Second (10 sec – 1 minute)
10 Second (1 minute – 60 minute)

Isolated Analogue Output (Current)

Range: 0 – 2.5V
Connector: 50 BNC sockets
Minimum load: 10 k

Isolated Analogue Output (Voltage)

Range: 0 – 2.7V
Connector: 50 BNC sockets
Minimum load: 10 k

Sampling Rate

40Hz (all parameters)

Display

LCD with backlight, 1Hz parameter refresh rate

Operating environment

Indoor: e.g. hospital or laboratory use
Temperature range: 15 – 30 °C
Atmospheric pressure: 80-106 kPa
Humidity: 0-80 %, non-condensing
Maximum Altitude: 2000m

Storage and transportation environment

Temperature range: 5 – 45 °C
Atmospheric pressure: 500 – 106 kPa
Humidity: 0 – 80 %, non-condensing

Power source

AC mains, 100-230 V, 50-60 Hz, 15 VA

Dimensions

235x80x200 mm (WxHxD) nominal

Weight

<3 kg

Mode of operation

Continuous

Electrical safety classification

Class I
Type BF applied parts

Medical devices classification

Class IIa Active device for diagnosis

Sterilisation method

None, equipment and probes Not intended to be sterilised