Cerebral Tissue Blood flow and Oxygen Assessment

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The ability to measure cerebral tissue blood flow and oxygen has proven valuable in a number of pre clinical and clinical research situations. Moor Instruments offer a number of assessment options for each application that have been well documented by publication and can be applied relatively easily, including

Cortical Spreading Depression

Image these travelling waves of blood flow with moorFLPI-2 High resolution laser speckle imaging for assessments in the pre-clinical and clinical settings. Cortical spreading depolarization (CSD) describes a wave of neuronal depolarization associated with influx of cat-ions and water which blocks normal cerebral activity. CSD induces changes to microvascular tone with the vasoconstriction phase (Cortical Spreading Ischemia, CSI) there is associated risk of progressive damage. CSI has been observed experimentally, replicating conditions following aneurysmal subarachnoid haemorrhage, and clinically, in ventilated patients. Pre-clinical and clinical research assessments are all performed with the moorFLPI-2 laser speckle system. Pre clinical assessments are performed with the desktop arm; a mobile, battery backed stand is offered for clinical measurements. The moorFLPI-2 offers exceptional performance with best spatial resolution of 10 microns per pixel.

Stroke Model

Laser Doppler monitoring with the latest option to combine tissue oxygen measurements with a small needle probe. Real-time measurements provide instant feedback and validity of surgical procedures. It is now considered a standard screening technique to confirm effective occlusion. Various probe options are available according to skull thickness and preferred surgical technique. The typical equipment selection will include moorVMS-LDF laser Doppler, with either needle or single fibre probes that are fixed to the skull surface, moorVMS-OXY tissue oxygen monitoring with moorVMS-PC software for easy data capture and visualisation, analysis, storage and reporting. Unprecedented manufacturers warranties and truly breakthrough pricing. Ask for our pre-clinical application note!


Dreier JP, Körner K, Ebert N, Görner A, Rubin I, Back T, et al. 1998 Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space. J Cereb Blood Flow Metab, 18, pp978–90

Dreier JP, Sebastian Major S, Manning A, Woitzik J et al. 2009 Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain, 132 , pp 1866–1881

Hecht N, Woitzik J, Dreier JP and Peter Vajkoczy P. 2009 Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis. Neurosurg Focus 27 (4):E11