Skin Heater Controller

#moorLAB-HEAT

Skin heater module offers flexible and reproducible skin heating protocols for flow/ oxygen response assessments

In a nutshell, moorFLPI-2 is the most user-friendly system for studying cerebral blood flow regulation in rodents.

Chia-Yi (Alex) Kuan, MD, PhD
Emory University School of Medicine
I expect to be using Moor Instrument’s technology for many years to come!

Faisel Khan, PhD
Ninewells Hospital & Medical School
It goes without saying that the company's imaging technology itself is superb!

Gourav Banerjee
Leeds Beckett University
I cannot rate the company or the staff highly enough.

Jim House, PhD
University of Portsmouth
We can't recommend Moor instruments highly enough. The technology is at the cutting edge and the support second to none.

Paul Sumners, PhD
London South Bank University
Moor Instruments have consistently provided excellent help and support for my research.

Kim Gooding, PhD
University of Exeter Medical School
We have found Moor equipment to be extremely dependable and innovative.

Dean L. Kellogg, Jr., MD, Ph.D
University of Texas Health Science Center
Laser Doppler Imager is a standard accurate method we now use in our cerebral blood flow and brain perfusion in our laboratory.

Momoh A. Yakubu, PhD
Texas Southern University

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moorLAB-HEAT Skin Heat Controller: Advanced Precision for Clinical Research

Optimise Tissue Heating for Enhanced Research Outcomes

moorLAB-HEAT Skin Heat Controller is designed specifically for research institutions to provide precise, programmable heating of skin tissue up to 45ºC.

This ensures enhanced reproducibility and accuracy in vascular and tissue oxygenation studies.

Key features include:

Dual-channel independent heating for accurate comparative analysis.
Programmable heating protocols for customised research needs.
Integration capability with Doppler blood flow monitors and tissue oxygenation monitors.
Precise temperature control (increments from 0.01ºC to 0.1ºC per second).

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The following products are AVAILABLE TO BUY ONLINE and work with the moorLAB-HEAT

LHAD

Adhesive Discs

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LHP-FP

A thick foam disc for use with the LHP3 imager probe

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LHP1A1

Needle probe adaptor

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LHP1H

Spare white acetal holder for LHP1 heater probe

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LIAD

Adhesive Discs

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TRANSFORMER-REO-MED300-SW

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This section lists the more common questions our customers have with regards to the moorVMS-HEAT. If you have a question you would like answered that does not appear below then please email us. We are happy to help!

Q. What is the moorVMS-HEAT used for?
A. The moorVMS-HEAT can be used to regulate the blood flow measurement temperature or it can be used to affect reproducible skin temperature changes as a stimulus for blood flow change.

Q. Is the moorVMS-HEAT a stand-alone skin-heating controller?
A. Yes, the moorVMS-HEAT can be used in a stand-alone mode or it can be controlled by moorVMS-PC software. This allows convenient connection of a number of skin heating and iontophoresis modules and full flexibility in the protocol set up.

Q. Can the moorVMS-HEAT be remotely controlled?
A. Yes, the moorVMS-HEAT can be remotely controlled by the moorVMS-PC software, where individual protocols detailing temperature and duration can be programmed.

Q. What is the temperature range of the moorVMS-HEAT?
A. The moorVMS-HEAT has a measurement range of 5-50°C and a heating range of 20-45°C (or ambient to 45°C, if the ambient temperature is greater than 20°C). Important: Ensure the temperature selected is appropriate for the subject to avoid risk of local burns.

Q. Can both channels of the moorVMS-HEAT be set to different temperatures - i.e. controlled independently?
A. Yes, the moorVMS-HEAT probes can be at different temperatures within each time period.

Q. Do you have to have two probes connected to the moorVMS-HEAT for it to work?
A. No, the moorVMS-HEAT will work with only one probe connected.

Q. Do I need to calibrate the moorVMS-HEAT probes?
A. There is no user calibration of the heater probes and new probes are supplied calibrated. We recommend annual factory servicing in order to ensure the system is operating within specification.

Q. When buying new probes for my moorVMS-HEAT, do I have to return the moorVMS-HEAT to calibrate the new probes?
A. No, new probes are calibrated by Moor Instruments without the need of returning the moorVMS-HEAT.

Q. Can I iontophorese and heat at the same time?
A. Yes, use the moorVMS-HEAT VHP2 digit-heating probe in the ION1r Iontophoresis chamber. The moorVMS-PC software allows simultaneous control of both skin heating and iontophoresis protocols.

Q. What optic probes do I use with the moorVMS-HEAT?
A. When using a moorVMS-LDF, you need to use a VP12. For the DRT4 you need to use a DP12-V2 and when using a moorLAB you need to use a MP12-V2.

Q. What adhesive discs do I need to order for my moorVMS-HEAT probes?
A. VHP1 you need to order SHAD.
VHP2 you need to order PAD.
VHP3 you need to order IAD or VHP-FP.

Q. Does the moorVMS-HEAT come with a warranty?
A. Yes, there is a 3-year warranty included with the purchase of a moorVMS-HEAT (the heating probes are covered by a 6 months warranty).

There are numerous references where our skin heaters are cited. The list below is a small selection. Please contact us for reference lists on your chosen subject.

Brunt, V. E., Miner, J. A., Meendering, J. R., Kaplan, P. F., and Minson, C. T., (2012).
17-β estradiol and progesterone independently augment cutaneous thermal hyperemia but not reactive hyperemia.
Microcirculation. 2011 Jul; 18(5): 347–355.
Weblink

Brunt, V. E., Eymann, T. M., Francisco, M. A., Howard, M. J., and Minson, C. T., (2016).
Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation.
Journal of Applied Physiology Published 14 July 2016 Vol. no. , DOI: 10.1152/japplphysiol.00424.2016.
Weblink

Van Duijnhoven, N. T. L., Janssen, T. W. J., Green, D. J., Minson, C. T., Hopman, M. T. E., and Thijssen, D. H. J., (2009).
Effect of functional electrostimulation on impaired skin vasodilator responses to local heating in spinal cord injury.
Journal of applied physiology (Bethesda, Md.: 1985), 106(4), pp.1065–71.
Weblink

Dupont, J. J., Farquhar, W. B., Townsend, R. R., and Edwards, D. G., (2011).
Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease.
Journal of applied physiology (Bethesda, Md.: 1985), 111(6), pp.1561–7.
Weblink

Harvey, J. C., Roseguini, B. T., Goerger, B., Fallon, E. A., and Wong, B. J., (2016).
Acute thermotherapy prevents impairments in cutaneous microvascular function induced by a high fat meal.
Journal of Diabetes Research. Submission Accepted 5th July 2016.
Weblink

Heimhalt-El Hamriti, M., Schreiver, C., Noerenberg, A., Scheffler, J., Jacoby, U., Haffner, D., and Fischer, D.C., (2013).
Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus.
Cardiovascular diabetology, 12(1), p.115.
Weblink

Holowatz, L. a, Jennings, J. D., Lang, J. a, and Kenney, W. L., (2009).
Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin.
Journal of applied physiology (Bethesda, Md.: 1985), 107(4), pp.1121–7.
Weblink

Holowatz, L. a, and Kenney, W. L., (2011)a.
Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans.
The Journal of physiology, 589(Pt 19), pp.4787–97.
Weblink

Holowatz, L. a, and Kenney, W. L., (2009).
Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans.
Journal of applied physiology (Bethesda, Md.: 1985), 106(2), pp.500–5.
Weblink

Holowatz, L. a, and Kenney, W. L., (2011)b.
Oral atorvastatin therapy increases nitric oxide-dependent cutaneous vasodilation in humans by decreasing ascorbate-sensitive oxidants.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(3), pp.R763–8.
Weblink

Holowatz, L. a, and Kenney, W. L., (2007).
Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans.
The Journal of physiology, 581(Pt 2), pp.863–72.

Holowatz, L. a, Santhanam, L., Webb, A., Berkowitz, D. E., and Kenney, W. L., (2011).
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans.
The Journal of physiology, 589(Pt 8), pp.2093–103.

Kuhlenhoelter, A. M., Kim, K., Neff, D., Nie, Y., Blaize, A. N., Wong, B. J., Kuang, S., Stout, J., Song, Q., Gavin, T. P., and Roseguini, B. T., (2016).
Heat therapy promotes the expression of angiogenic regulators in human skeletal muscle.
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. DOI:10.1152/ajpregu.00134.2016.

Lang, J. a., Holowatz, L. a., and Kenney, W. L., (2009).
Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans.
The Journal of physiology, 587(Pt 15), pp.3967–74.

Nabavi Nouri, M., Ahmed, A., Bril, V., Orszag, A., Ng, E., Nwe, P., and Perkins, B.a., (2012).
Diabetic neuropathy and axon reflex-mediated neurogenic vasodilatation in type 1 diabetes.
PloS one, 7(4), p.e34807.

Petrofsky, J., Alshammari, F., Khowailed, I. A., Rodrigues, S., Potnis, P., Akerkar, S., Shah, J., Chung, G., and Save, R., (2013).
The effect of acute administration of vitamin D on micro vascular endothelial function in Caucasians and South Asian Indians.
Medical science monitor: international medical journal of experimental and clinical research, 19, pp.641–7.

Wong, B., and Minson, C., (2011).
Altered thermal hyperaemia in human skin by prior desensitization of neurokinin-1 receptors.
Experimental physiology, 96(6), pp.599–609.

Analogue outputs

Range: 0 – 5 V
Number of outputs: 2
Connectors: BNC sockets

Electrical safety classification

Class I (protectively earthed)

Electromagnetic compatibility

The moorLAB-HEAT complies with the requirements of EN 61326-1:2021 Electromagnetic compatibility of electrical equipment for measurement, control and laboratory use. The moorLAB-HEAT is suitable for use in a basic electromagnetic environment such as a laboratory. It is suitable for use in all locations other than those allocated in residential environments and those directly connected to a low voltage power supply network which supplies buildings used for domestic purposes.

Intended use

The moorLAB-HEAT skin heater and temperature monitor is intended for the localised heating of skin. The moorLAB-HEAT is intended for use in research and educational life science applications only. The moorLAB-HEAT is not a medical device and is not intended for use with human subjects for any of the following specific medical purposes:

Diagnosis, prevention, monitoring, prediction, prognosis, treatment or alleviation of disease.
Diagnosis, monitoring, treatment, alleviation of, or compensation for, an injury or disability.
Investigation, replacement or modification of the anatomy or of a physiological or pathological process or state.

Measured parameters

Temperature
Range: 5 – 50ºC
Accuracy: ±0.5ºC Sampling rate (all parameters) 40Hz

Method of cleaning

Wiping with a cloth soaked in isopropanol or a mixture of isopropanol and water.

Method of sterilisation

Not suitable for sterilisation

Mode of operation

Continuous

Number of measurement channels

Operating environment

Indoor laboratory use Temperature range: 15 – 30ºC
Atmospheric pressure: 75 – 106 kPa
Humidity: 0 – 75%, non-condensing
Maximum altitude: 2000 m
Pollution degree: 2

Power source

AC mains, 100-230V ±10%, 50-60Hz, 30 VA

Storage and transportation environment

Temperature range: 5 – 45ºC
Atmospheric pressure: 75 – 106 kPa
Humidity: 0 – 75%, non-condensing

Temperature control

Range: 20°C (or ambient) to 47°C
Resolution: 0.1°C

Weight

Under 3kg

Moor Instruments manufacture a wide range of probes designed to help you assess flow from almost any tissue. We are more than happy to advise on your particular application but hope too that the following general notes are useful.

LHP1

Standard heating probe

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LHP2

Small heating probe for digit/small area

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LHP3

A water-filled clear heating probe

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