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Iontophoresis Controller

Iontophoresis Controller

#moorLAB-ION

Transdermal drug delivery by iontophoresis

  • In a nutshell, moorFLPI-2 is the most user-friendly system for studying cerebral blood flow regulation in rodents.

    Chia-Yi (Alex) Kuan, MD, PhD
    Emory University School of Medicine

  • We have found Moor equipment to be extremely dependable and innovative.

    Dean L. Kellogg, Jr., MD, Ph.D
    University of Texas Health Science Center

  • Laser Doppler Imager is a standard accurate method we now use in our cerebral blood flow and brain perfusion in our laboratory.

    Momoh A. Yakubu, PhD
    Texas Southern University

  • I cannot rate the company or the staff highly enough.

    Jim House, PhD
    University of Portsmouth

  • I expect to be using Moor Instrument’s technology for many years to come!

    Faisel Khan, PhD
    Ninewells Hospital & Medical School

  • Moor Instruments have consistently provided excellent help and support for my research.

    Kim Gooding, PhD
    University of Exeter Medical School

  • We can't recommend Moor instruments highly enough. The technology is at the cutting edge and the support second to none.

    Paul Sumners, PhD
    London South Bank University

  • It goes without saying that the company's imaging technology itself is superb!

    Gourav Banerjee
    Leeds Beckett University

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moorLAB-ION: Precision Iontophoresis Controller for Research Applications

Consistent, Reliable Results for Advanced Endothelial Studies

Optimise your endothelial and smooth muscle function research with the moorLAB-ION Iontophoresis Controller.

Specifically designed for research communities across Europe, including universities, research hospitals and private labs, the Iontophoresis Controller provides precise control and integration with Moor Instruments’ comprehensive monitoring and imaging solutions.

Enhance your experimental accuracy, streamline your workflow, and significantly reduce consumable expenses with reusable chambers.

The Iontophoresis controller ensures this current is precisely controlled, offering consistent, measurable stimulation to microcirculation when used alongside Moor Instruments’ advanced monitoring and imaging equipment.

Key Benefits:

  • Proven Reliability: Used by researchers worldwide for consistent, clearly defined results.
  • Cost Efficiency: Reusable chambers significantly reduce ongoing consumable expenses.
  • Comprehensive Compatibility: Seamless integration with Moor Instruments’ blood flow and oxygen monitors, imagers, and software, providing a complete research solution.

Compatible Moor Instruments:

Disclaimer: The moorLAB-ION controller is intended solely for research and is not suitable for hyperhidrosis (excessive sweating) treatment or drug delivery for therapeutic purposes.

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The following products are AVAILABLE TO BUY ONLINE and work with the moorLAB-ION

LIAD

Adhesive Discs

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LIC-CP-V2

LIC-CP-V2

2 conductive pads

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LIC-GP

LIC-GP

20 gel pads

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LIC-ION1R-P1

LIC-ION1R-P1

ION Chamber

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LIC-ION3-P2

LIC-ION3-P2

ION Chamber

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LIC-ION6-CAP

LIC-ION6-CAP

LIC-ION6 chamber cover

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LIC-ION6+CAP

LIC-ION6+CAP

ION Chamber

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LIC-Y3

LIC-Y3

moorLAB-ION output lead

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TRANSFORMER-REO-MED300-SW

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There are numerous references where our iontophoresis controllers are cited. Below is a small selection of references in the key application areas. If you don’t see your topic covered or have any questions about your intended application, please do not hesitate to contact our application specialists. We would also be happy to include your reference below!

Clinical Research
Technical

Clinical Research


A K Andreassen, L Gullestad, T Holm, S Simonsen, K Kvernebo (1998).
Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients.
Clin Transplant. 1998 Aug;12(4):324-32.
Weblink

Anthony I Shepherd, Joseph T Costello, Stephen J Bailey, Nicolette Bishop, Alex J Wadley, Steven Young-Min, Mark Gilchrist, Harry Mayes, Danny White, Paul Gorczynski, Zoe L Saynor, Heather Massey, Clare M Eglin (2019).
"Beet" the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud's phenomenon.
J Appl Physiol (1985). 2019 Nov 1;127(5):1478-1490.
Weblink

Bridgette L Jones, Gregory Kearns, Kathleen A Neville, Catherine M T Sherwin, Michael M G Spigarelli, J Steven Leeder (2013).
Variability of histamine pharmacodynamic response in children with allergic rhinitis.
J Clin Pharmacol. 2013 Jul;53(7):731-7.
Weblink

Dag Olav Dahle, Karsten Midtvedt, Anders Hartmann, Trond Jenssen, Hallvard Holdaas, Geir Mjøen, Torbjørn Leivestad, Anders Asberg (2013).
Endothelial dysfunction is associated with graft loss in renal transplant recipients.
Transplantation. 2013 Mar 15;95(5):733-9.
Weblink

Deepankar Datta, William R Ferrell, Roger D Sturrock, Sachin T Jadhav, Naveed Sattar (2007).
Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis.
Atherosclerosis. 2007 Jun;192(2):391-5.
Weblink

Dimitroulas T, Hodson J, Sandoo A, Smith J, Kitas GD. (2017).
Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation
Arthritis Research & Therapy. 2017; 19: 32.
Weblink

E F Willis, G F Clough, M K Church (2004).
Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo.
Clin Exp Allergy. 2004 Mar;34(3):450-5.
Weblink

F Casanova, D D Adingupu, F Adams, K M Gooding, H C Looker, K Aizawa, F Dove, S Elyas, J J F Belch, P E Gates, R C Littleford, M Gilchrist, H M Colhoun, A C Shore, F Khan, W D Strain (2017).
The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control.
Cardiovasc Diabetol. 2017 Sep 15;16(1):114.
Weblink

Faisel Khan, Jill J F Belch, Maureen MacLeod, Gary Mires (2005).
Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops.
Hypertension. 2005 Nov;46(5):1123-8.
Weblink

Heimhalt-El Hamriti M, Schreiver C, Noerenberg A, Scheffler J, Jacoby U, Haffner D, Fischer DC. (2013).
Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus.
Cardiovascular Diabetology. 2013 Aug 12;12:115. doi: 10.1186/1475-2840-12-115.
Weblink

Jason M R Gill, Ali Al-Mamari, William R Ferrell, Stephen J Cleland, Chris J Packard, Naveed Sattar, John R Petrie, Muriel J Caslake (2004).
Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men.
J Am Coll Cardiol. 2004 Dec 21;44(12):2375-82.
Weblink

Junette S Mohan, Gregory Y H Lip, Andrew D Blann, David Bareford, Janice M Marshall (2011).
Endothelium-dependent and endothelium independent vasodilatation of the cutaneous circulation in sickle cell disease.
Eur J Clin Invest. 2011 May;41(5):546-51.
Weblink

Khan F, George J, Wong K, McSwiggan S, Struthers AD, Belch JJ. (2008).
The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors.
Atherosclerosis. October 2008, Volume 200, Issue 2, Pages 374–379.
Weblink

Malia S Q Murphy, Meera Vignarajah, Graeme N Smith (2014).
Increased microvascular vasodilation and cardiovascular risk following a pre-eclamptic pregnancy.
Physiol Rep. 2014 Nov 26;2(11):e12217.
Weblink

Murphy MSQ, Vignarajah M, Smith GN. (2014).
Increased microvascular vasodilation and cardiovascular risk following a pre‐eclamptic pregnancy
Physiological Reports. 2014 Nov; 2(11): e12217.
Weblink

P R Pienaar, L K Micklesfield, J M R Gill, A C Shore, K M Gooding, N S Levitt, E V Lambert (2014).
Ethnic differences in microvascular function in apparently healthy South African men and women.
Exp Physiol. 2014 Jul;99(7):985-94.
Weblink

Paul J Meakin, Bethany M Coull, Zofia Tuharska, Christopher McCaffery, Ioannis Akoumianakis, Charalambos Antoniades, Jane Brown, Kathryn J Griffin, Fiona Platt, Claire H Ozber, Nadira Y Yuldasheva, Natallia Makava, Anna Skromna, Alan Prescott, Alison D McNeilly, Moneeza Siddiqui, Colin Na Palmer, Faisel Khan, Michael Lj Ashford (2020).
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
J Clin Invest. 2020 Aug 3;130(8):4104-4117.
Weblink

Peter J Connelly, Fiona Adams, Ziad I Tayar, Faisel Khan (2019).
Peripheral vascular responses to acetylcholine as a predictive tool for response to cholinesterase inhibitors in Alzheimer's disease.
BMC Neurol. 2019 May 3;19(1):88.
Weblink

Turner J, Belch JJ, Khan F. (2008).
Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis.
Trends in cardiovascular medicine. 2008 May;18(4):109-16.
Weblink

Technical


Faisel Khan, David J Newton, Emily C Smyth, Jill J F Belch (2004).
Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans.
J Appl Physiol (1985). 2004 Sep;97(3):883-7.
Weblink

Grossmann M, Jamieson MJ, Kellogg DL Jr, Kosiba WA, Pergola PE, Crandall CG, Shepherd AM. (1995).
The Effect of Iontophoresis on the Cutaneous Vasculature: Evidence for Current-Induced Hyperemia.
Microvascular Research. Volume 50, Issue 3, November 1995, Pages 444-452.
Weblink

Pierre Abraham, Mélissa Bourgeau, Maïte Camo, Anne Humeau-Heurtier, Sylvain Durand, Pascal Rousseau, Guillaume Mahe (2013).
Effect of skin temperature on skin endothelial function assessment.
Microvasc Res. 2013 Jul;88:56-60.
Weblink

S Kubli, B Waeber, A Dalle-Ave, F Feihl (2000).
Reproducibility of laser Doppler imaging of skin blood flow as a tool to assess endothelial function.
J Cardiovasc Pharmacol . 2000 Nov;36(5):640-8.
Weblink

Moor Instruments are committed to product development. We reserve the right to change the specifications below without notice.

Analogue outputs

Current: 0 – 2.5 V, 1 V = 100 μA
Voltage: 0 – 2.7 V, 1 V = 10V
Connectors: BNC sockets
Minimum load resistance: 10 kΩ

Current measurement

Range: 0-250 μA
Accuracy: ± 0.5 μA
Resolution: 0.1 μA

Current output

Range: 1-250 μA
Accuracy: ± 0.5 μA
Output current step: 0.1 μA (1-10 μA)
1 μA (10-250 μA)
Compliance voltage: 27 V ±2 V

Dimensions

235x60x200 mm (WxHxD) nominal

Electrical safety classification

Class I (protectively earthed)

Intended use

The moorLAB-ION iontophoresis controller is intended to deliver a controlled electrical current between two chambers or electrodes attached to the skin. The moorLAB-ION is intended for use in research and educational life science applications only. The moorLAB-ION is not a medical device and is not intended for use with human subjects for any of the following specific medical purposes:

  • Diagnosis, prevention, monitoring, prediction, prognosis, treatment or alleviation of disease.
  • Diagnosis, monitoring, treatment, alleviation of, or compensation for, an injury or disability.
  • Investigation, replacement or modification of the anatomy or of a physiological or pathological process or state.
  • Delivery of drugs or other medicinal substances for diagnostic or therapeutic purposes.

Iontophoresis timer

10 seconds – 60 minutes

Method of cleaning

Main body of device:

  • Wiping with a cloth soaked in isopropanol or a mixture of isopropanol and water.

Chambers, excluding connecting leads:

  • Wiping with a cloth soaked in isopropanol or a mixture of isopropanol and water.
  • Washing in running water.
  • Cleaning in warm water with a neutral or enzymatic detergent.

Method of sterilisation

Not suitable for sterilisation

Mode of operation

Continuous

Operating environment

Indoor laboratory use Temperature range: 15 – 30ºC
Atmospheric pressure: 75 – 106 kPa
Humidity: 0 – 75%, non-condensing
Maximum altitude: 2000 m
Pollution degree: 2

Power source

AC mains, 100-230V ±10%, 50-60Hz, 15 VA

Resistance measurement

Range: 1 kΩ – 20 MΩ
Accuracy: ±5% 1 kΩ – 20 MΩ, for output voltage >0.2 V

Storage and transportation environment

Temperature range: 5 – 45ºC
Atmospheric pressure: 75 – 106 kPa
Humidity: 0 – 75%, non-condensing

Voltage measurement

Range: 0 to compliance voltage
Accuracy: ± 100 mV
Resolution: 10 mV (<10 V), 100 mV (>10 V)

Weight

Under 3kg

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