Wheal and Flare Response (WFR)
The wheal and flare response (WFR) is the common reference to the triple response described by Lewis; erythema at site of injury, a spreading flare in the surrounding skin followed by pallor around the centre, as oedema develops due to leaking capillaries.
Wheal and flare response (WFR) can be induced by local introduction of histamine into the skin by lancet, intra-dermal injection or by micro-dialysis. The microvascular blood flow response is most graphically visualised by laser Doppler imaging or speckle imaging and enables the investigation of mechanisms of wheal and flare response (WFR) and treatments that inhibit it.
Laser Doppler imaging has been used historically and could still be used. However, the high spatial and time resolution offered by moorFLPI-2 laser speckle contrast imager make it the ideal system.
Laser Speckle Contrast Imager
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