Cortical Spreading Depression (CSD)
Cortical spreading depression (CSD), also known as cortical spreading depolarization, describes a wave of neuronal depolarization associated with influx of cat-ions and water which blocks normal cerebral activity. CSD induces changes to microvascular tone with the vasoconstriction phase (Cortical Spreading Ischeamia, CSI) with associated risk of progressive damage. The waves move relatively slowly and experimental areas of the cerebral cortex are relatively small.
Anaesthesia choice has been found to have a significant impact on cerebral auto-regulation; investigations found that auto-regulation of cerebral tissue blood flow, assessed by moorFLPI-2, was preserved with Ethomidate down to about 27mmHg mean arterial pressure (MAP) whereas with several other anaesthetics, cerebral auto-regulation was abolished and a linear relationship between cerebral tissue blood flow and MAP was observed.
Laser Speckle Contrast Imager
moorFLPI-2 - Vollfeld-Videobildfrequenz-Blutflussbildgebung
MOORFLPI-MICROSTAND - moorFLPI Mikroständer